Our scientific interests

The Court lab is located in the Center for Integrative Biology at Universidad Mayor, in Santiago, Chile, with access to different laboratory models and behavioral tests, and state of the art facilities for microscopy and biochemical analysis.

We study the mechanisms of axonal degeneration and regeneration in the peripheral and central nervous systems, interested in the communication between glial cells and neurons, as well as tissular changes associated to the aging process. We are especially interested in defining subcellular processes taking place in the axonal compartment, including locally controlled regenerative and degenerative mechanisms.

Associated to axonal degeneration, we have defined the participation different steps of the process, and shown their impact in the degeneration of peripheral and central axons in relevant models of brain diseases, aging of the nervous system, as well as in peripheral neuropathies.

We are also investigating the capacity for glia to axon communication through the transfer of genetic material by extracellular vesicles in the context of axonal regeneration in the peripheral nervous system, and different phenotypes acquired by Schwann cells after injury induced cell reprogramming.

Funding

Present Projects

FONDAP

Geroscience Center for Brain Health and Metabolism

PI Felipe Court, Cesar Cárdenas

Universidad Mayor

(2020-2025)

Proyecto Internacional

Targeting necroptosis to inhibit early axonal degeneration in Parkinson’s disease

PI Felipe Court

Universidad Mayor

(2019-2021)

CONICYT ECOS-Chile

Investigating the role of caveolae-dependent mechanosensing in glial cells interaction with neurons

PI Felipe Court

Universidad Mayor

(2017-2020)

FONDECYT REGULAR

Participation of NAD-dependent necroptosis activation in the mechanisms associated to the axonal degeneration program

PI Felipe Court

Universidad Mayor

(2019-2023)

FONDEF

Machine learning para el diagnóstico precoz y perfil multimodal de la Enfermedad de Alzheimer basado en miRNA de exosomas circulantes

PI Claudia Duran, Felipe Court

Universidad Mayor

(2020-2024)

CONICYT REDES

A multimodel collaborative network to study develpment and function of the nervous system in health and disease

PI Felipe Court

Universidad Mayor

(2018-2020)

Past Projects

FONDECYT Regular

Glia-to-axon transfer of ribosomes: Pathway and regulatory mechanisms

PI Felipe Court

Pontificia Universidad Católica de Chile

(2007-2010)

Proyecto Internacional

Role of UPR in locomotor recovery after Spinal cord injury

PI Felipe Court, Claudio Hetz

Universidad de Chile

(2010-015)

FONDECYT Regular

Mechanisms involved in the axonal degeneration program: role of oxidative stress and mitochondrial dysfunction

PI Felipe Court

Pontificia Universidad Católica de Chile

(2011-2014)

CONICYT FONDEF

Estimulación de la recuperación locomotora luego del daño a la medula espinal utilizando activadores vesiculares derivados de células gliales periféricas

PI Felipe Court

Pontificia Universidad Católica de Chile

(2013-2015)

Iniciativa Milenio

Millenium Nucleus in Regenerative Biology (MINREB, Renovacion)

PI Francisca Bronfman

Pontificia Universidad Católica de Chile

(2014-2016)

Proyecto Internacional

Circuit Formation by Spatio-Temporal Control of Messenger RNA Translation

PI Felipe Court, Avraham Yaron

Universidad Mayor

(2016-2019)

FONDEF

Botanic drug for the treatment of Insulin resistance and Diabetes type II and its evaluation in neurodegenerative diseases.

PI Miguel Bronfman

Pontificia Universidad Católica de Chile

(2010-2013)

Iniciativa Milenio

Millenium Nucleus in Regenerative Biology (MINREB)

PI María Paz Marzolo

Pontificia Universidad Católica de Chile

(2011-2014)

Proyecto Internacional

Role of Cellular Stress in locomotor recovery after Spinal cord injury

PI Felipe Court, Claudio Hetz

Pontificia Universidad Católica de Chile

(2012-2015)

CONICYT

Neuronal network-based initiative (NBI): Understanding the causes of neuronal vulnerability in disease

PI Felipe Court

Pontificia Universidad Católica de Chile

(2013-2015)

FONDECYT Regular

Transfer of RNA from Schwann cell to neurons mediated by exosomes: impact upon axonal regeneration and neuronal survival

PI Felipe Court

Universidad Mayor

(2015-2018)