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PUBLICATIONSNeuroDegenerationAGING
April 19, 2023
Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation.
Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo Cerpa,Thomas M. Wishart, Felipe A. Court
Aging Cell. Mar 27;e13814. doi: 10.1111/acel.13814. Online ahead of print.
PUBLICATIONSBioRxivNeuroRegenerationAGING
January 25, 2023
Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury
Andrés Fuentes-Flores, Cristian Geronimo-Olvera, David Ñecuñir, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Hoke, Jose A. Gomez-Sanchez, Birgit Schilling, Judith Campisi, Felipe A. Court
PUBLICATIONSDataPNSNeuroRegeneration
September 26, 2022
Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading
Cristian Saquel, Romina J. Catalan, Rodrigo Lopez-Leal, Ramon A. Ramirez, David Necuñir, Ursula Wyneken, Christophe Lamaze and Felipe A. Court
PUBLICATIONSDataCNSNeuroDegeneration
August 29, 2022
An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research
Rachel A. Kline, Lena Lößlein, Dominic Kurian, Judit Aguilar Martí, Samantha L. Eaton,
Felipe A. Court, Thomas H. Gillingwater, and Thomas M. Wishart
PUBLICATIONSDataNervous System FxCNSNeuroDegenerationAGING
August 8, 2022
Commentary on “PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons”
Macarena S. Arrázola, Court FA.
PMID: 35900426
PUBLICATIONSDataCNSNeuroDegenerationAGING
June 3, 2022
Multiple events case–control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity‑induced accelerated aging in 30‑years‑olds: the ObAGE study protocol
Correa‑Burrows P, Burrows R, Albala C, Court FA, Salech F, Sanhueza G and Gonzalez‑Billault C.
PMID: 35501766
PUBLICATIONSDataCNSNeuroDegenerationAGING
March 24, 2022
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
Natalia Salvadores, Ines Moreno‑Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas‑Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto and Felipe A. Court.
PMID: 35264247
PUBLICATIONSBioRxivNeuroDegenerationAGING
November 25, 2021
Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation.
Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo Cerpa,Thomas M. Wishart, Felipe A. Court
bioRxiv doi: https://doi.org/10.1101/2021.11.10.468052
PUBLICATIONSDataCNSNeuroDegenerationAGING
October 7, 2021
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
Gorostieta-Salas E, Moreno-Blas D, Gerónimo-Olvera C, Cisneros B, Court FA, Castro-Obregón S.
Oxid Med Cell Longev. 2021 Aug 13;2021:6682336. doi: 10.1155/2021/6682336. eCollection 2021.
PMID: 34434486
PUBLICATIONSReviewPNSNeuroRegeneration
October 7, 2021
New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury.
Lemaitre D, Court FA.
Neural Regen Res. 2021 Sep;16(9):1760-1761. doi: 10.4103/1673-5374.306069.
PMID: 33510065
PUBLICATIONSReviewCNSNeuroDegenerationAGING
October 7, 2021
Dementia in Latin America: Paving the way toward a regional action plan.
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A.
Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.
PMID: 33634602
PUBLICATIONSProtocolCNSNeuroDegenerationAGING
October 7, 2021
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly.
Slachevsky A, Zitko P, Martínez-Pernía D, Forno G, Court FA, Lillo P, Villagra R, Duran-Aniotz C, Parrao T, Assar R, Orellana P, Toledo C, Rivera R, Ibañez A, Parra MA, González-Billault C, Amieva H, Thumala D.
BMC Geriatr. 2020 Nov 25;20(1):505. doi: 10.1186/s12877-020-01866-4.
PMID: 33238908
PUBLICATIONSReviewCNSNeuroDegenerationAGING
October 7, 2021
Axonal Degeneration in AD: The Contribution of Aβ and Tau.
Salvadores N, Gerónimo-Olvera C, Court FA.
Front Aging Neurosci. 2020 Oct 15;12:581767. doi: 10.3389/fnagi.2020.581767. eCollection 2020.
PMID: 33192476
PUBLICATIONSChapterProtocolPNSNeuroDegeneration
October 7, 2021
Ex Vivo Analysis of Axonal Degeneration Using Sciatic and Optic Nerve Preparations.
López-Leal R, Court FA.
Methods Mol Biol. 2020;2143:179-189. doi: 10.1007/978-1-0716-0585-1_14.
PMID: 32524481
PUBLICATIONSDataCNSNeuroDegeneration
October 7, 2021
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates.
García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL, Hetz C.
Acta Neuropathol. 2020 Nov;140(5):737-764. doi: 10.1007/s00401-020-02183-1. Epub 2020 Jul 8.
PMID: 32642868