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PUBLICATIONSDataCNSAlzheimerNeuroDegenerationAGING
March 24, 2022
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
Natalia Salvadores, Ines Moreno‑Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas‑Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto and Felipe A. Court.
PMID: 35264247
PUBLICATIONSBioRxivNeuroDegenerationAGING
November 25, 2021
Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation.
Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo Cerpa,Thomas M. Wishart, Felipe A. Court
bioRxiv doi: https://doi.org/10.1101/2021.11.10.468052
PUBLICATIONSDataCNSNeuroDegenerationAGING
October 7, 2021
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
Gorostieta-Salas E, Moreno-Blas D, Gerónimo-Olvera C, Cisneros B, Court FA, Castro-Obregón S.
Oxid Med Cell Longev. 2021 Aug 13;2021:6682336. doi: 10.1155/2021/6682336. eCollection 2021.
PMID: 34434486
PUBLICATIONSReviewPNSNeuroRegeneration
October 7, 2021
New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury.
Lemaitre D, Court FA.
Neural Regen Res. 2021 Sep;16(9):1760-1761. doi: 10.4103/1673-5374.306069.
PMID: 33510065
PUBLICATIONSReviewCNSNeuroDegenerationAGING
October 7, 2021
Dementia in Latin America: Paving the way toward a regional action plan.
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A.
Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.
PMID: 33634602
PUBLICATIONSProtocolCNSNeuroDegenerationAGING
October 7, 2021
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly.
Slachevsky A, Zitko P, Martínez-Pernía D, Forno G, Court FA, Lillo P, Villagra R, Duran-Aniotz C, Parrao T, Assar R, Orellana P, Toledo C, Rivera R, Ibañez A, Parra MA, González-Billault C, Amieva H, Thumala D.
BMC Geriatr. 2020 Nov 25;20(1):505. doi: 10.1186/s12877-020-01866-4.
PMID: 33238908
PUBLICATIONSReviewCNSNeuroDegenerationAGING
October 7, 2021
Axonal Degeneration in AD: The Contribution of Aβ and Tau.
Salvadores N, Gerónimo-Olvera C, Court FA.
Front Aging Neurosci. 2020 Oct 15;12:581767. doi: 10.3389/fnagi.2020.581767. eCollection 2020.
PMID: 33192476
PUBLICATIONSChapterProtocolPNSNeuroDegeneration
October 7, 2021
Ex Vivo Analysis of Axonal Degeneration Using Sciatic and Optic Nerve Preparations.
López-Leal R, Court FA.
Methods Mol Biol. 2020;2143:179-189. doi: 10.1007/978-1-0716-0585-1_14.
PMID: 32524481
PUBLICATIONSDataCNSNeuroDegeneration
October 7, 2021
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates.
García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL, Hetz C.
Acta Neuropathol. 2020 Nov;140(5):737-764. doi: 10.1007/s00401-020-02183-1. Epub 2020 Jul 8.
PMID: 32642868
PUBLICATIONSDataPNSNeuroRegeneration
October 7, 2021
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile.
Lemaitre D, Hurtado ML, De Gregorio C, Oñate M, Martínez G, Catenaccio A, Wishart TM, Court FA.
Mol Neurobiol. 2020 Oct;57(10):4232-4249. doi: 10.1007/s12035-020-01986-3. Epub 2020 Jul 21.
PMID: 32696431
PUBLICATIONSDataPNSNeuroDegeneration
October 7, 2021
Metformin protects from oxaliplatin induced peripheral neuropathy in rats.
Martinez NW, Sánchez A, Diaz P, Broekhuizen R, Godoy J, Mondaca S, Catenaccio A, Macanas P, Nervi B, Calvo M, Court FA.
Neurobiol Pain. 2020 May 22;8:100048. doi: 10.1016/j.ynpai.2020.100048. eCollection 2020 Aug-Dec.
PMID: 32490289
PUBLICATIONSDataNervous System FxPNSNeuroRegeneration
October 7, 2021
Schwann Cell Reprogramming Into Repair Cells Increases Exosome-Loaded miRNA-21 Promoting Axonal Growth.
López-Leal R, Díaz-Viraqué F, Catalán RJ, Saquel C, Enright A, Iraola G, Court FA.
J Cell Sci. 2020 Jun 15;133(12):jcs239004. doi: 10.1242/jcs.239004.
PMID: 32409566
PUBLICATIONSReviewNeuroDegenerationAGING
October 7, 2021
The Necroptosis Pathway and Its Role in Age-Related Neurodegenerative Diseases: Will It Open Up New Therapeutic Avenues in the Next Decade?
Salvadores N, Court FA.
Expert Opin Ther Targets. 2020 Jul;24(7):679-693. doi: 10.1080/14728222.2020.1758668. Epub 2020 May 4
PMID: 32310729
PUBLICATIONSDataCNSNeuroDegenerationAGING
October 7, 2021
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease.
Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA.
Cell Death Differ. 2020 Apr;27(4):1169-1185. doi: 10.1038/s41418-019-0408-4. Epub 2019 Oct 7.
PMID: 31591470
PUBLICATIONSDataNervous System FxPNS
October 7, 2021
The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability.
Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP.
Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.
PMID: 31514753