PUBLICATIONSDataCNSNeuroDegeneration
octubre 7, 2021
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates.
García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL, Hetz C.
Acta Neuropathol. 2020 Nov;140(5):737-764. doi: 10.1007/s00401-020-02183-1. Epub 2020 Jul 8.
PMID: 32642868
PUBLICATIONSDataPNSNeuroRegeneration
octubre 7, 2021
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile.
Lemaitre D, Hurtado ML, De Gregorio C, Oñate M, Martínez G, Catenaccio A, Wishart TM, Court FA.
Mol Neurobiol. 2020 Oct;57(10):4232-4249. doi: 10.1007/s12035-020-01986-3. Epub 2020 Jul 21.
PMID: 32696431
PUBLICATIONSDataPNSNeuroDegeneration
octubre 7, 2021
Metformin protects from oxaliplatin induced peripheral neuropathy in rats.
Martinez NW, Sánchez A, Diaz P, Broekhuizen R, Godoy J, Mondaca S, Catenaccio A, Macanas P, Nervi B, Calvo M, Court FA.
Neurobiol Pain. 2020 May 22;8:100048. doi: 10.1016/j.ynpai.2020.100048. eCollection 2020 Aug-Dec.
PMID: 32490289
PUBLICATIONSDataNervous System FxPNSNeuroRegeneration
octubre 7, 2021
Schwann Cell Reprogramming Into Repair Cells Increases Exosome-Loaded miRNA-21 Promoting Axonal Growth.
López-Leal R, Díaz-Viraqué F, Catalán RJ, Saquel C, Enright A, Iraola G, Court FA.
J Cell Sci. 2020 Jun 15;133(12):jcs239004. doi: 10.1242/jcs.239004.
PMID: 32409566
PUBLICATIONSReviewNeuroDegenerationAGING
octubre 7, 2021
The Necroptosis Pathway and Its Role in Age-Related Neurodegenerative Diseases: Will It Open Up New Therapeutic Avenues in the Next Decade?
Salvadores N, Court FA.
Expert Opin Ther Targets. 2020 Jul;24(7):679-693. doi: 10.1080/14728222.2020.1758668. Epub 2020 May 4
PMID: 32310729
PUBLICATIONSDataCNSNeuroDegenerationAGING
octubre 7, 2021
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease.
Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA.
Cell Death Differ. 2020 Apr;27(4):1169-1185. doi: 10.1038/s41418-019-0408-4. Epub 2019 Oct 7.
PMID: 31591470
PUBLICATIONSDataNervous System FxPNS
octubre 7, 2021
The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability.
Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP.
Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.
PMID: 31514753
PUBLICATIONSDataNervous System FxPNS
octubre 7, 2021
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC.
Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6.
PMID: 30988348
octubre 7, 2021
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.
Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.
Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20.
PMID: 31110288
PUBLICATIONSDataPNSNeuroDegeneration
octubre 5, 2021
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.
Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM.
Neurobiol Dis. 2019 Oct;130:104496. doi: 10.1016/j.nbd.2019.104496. Epub 2019 Jun 6.
PMID: 31176719
PUBLICATIONSDataPNSCNSNeuroDegeneration
octubre 5, 2021
Axonal degeneration is mediated by necroptosis activation.
Arrázola MS, Saquel C, Catalán RJ, Barrientos SA, Hernandez DE, Martínez NW, Catenaccio A, Court FA.
J Neurosci. 2019 May 15;39(20):3832-3844. doi: 10.1523/JNEUROSCI.0881-18.2019. Epub 2019 Mar 8.
PMID: 30850513
PUBLICATIONSReviewPNSCNSNeuroDegeneration
octubre 5, 2021
Compartmentalized necroptosis activation in excitotoxicityinduced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology.
Arrazola MS, Court FA.
Neural Regen Res. 2019 Aug;14(8):1385-1386. doi: 10.4103/1673-5374.253520.
PMID: 30964063
PUBLICATIONSDataPNSNeuroDegeneration
octubre 5, 2021
A dual role for Integrin α6β4 in modulating Hereditary Neuropathy with liability to Pressure Palsies.
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML.
J Neurochem. 2018 May;145(3):245-257. doi: 10.1111/jnc.14295. Epub 2018 Feb 13.
PMID: 29315582
PUBLICATIONSChapterProtocolPNSNeuroDegenerationNeuroRegeneration
octubre 5, 2021
In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia.
López-Leal R, Diaz P, Court FA.
Methods Mol Biol. 2018;1739:255-267. doi: 10.1007/978-1-4939-7649-2_16.
PMID: 29546712
PUBLICATIONSChapterProtocolNervous System FxPNS
octubre 5, 2021
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs.
De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA.
Methods Mol Biol. 2018;1739:299-315. doi: 10.1007/978-1-4939-7649-2_19.
PMID: 29546715