PUBLICATIONSDataPNSCNSNeuroDegeneration
octubre 5, 2021
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling.
Rojas F, Gonzalez D, Cortes N, Ampuero E, Hernández DE, Fritz E, Abarzua S, Martinez A, Elorza AA, Alvarez A, Court F, van Zundert B.
Front Cell Neurosci. 2015 Jun 9;9:203. doi: 10.3389/fncel.2015.00203. eCollection 2015.
PMID: 26106294
PUBLICATIONSDataPNSNeuroRegeneration
octubre 5, 2021
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration.
Kerr B, Court FA, Hetz C.
PLoS One. 2015 Sep 11;10(9):e0136620. doi: 10.1371/journal.pone.0136620. eCollection 2015.
PMID: 26361352
PUBLICATIONSDataPNSNeuroRegeneration
octubre 5, 2021
ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1.
Pasten C, Cerda J, Jausoro I, Court FA, Cáceres A, Marzolo MP.
Mol Cell Neurosci. 2015 Nov;69:1-11. doi: 10.1016/j.mcn.2015.09.004. Epub 2015 Sep 16.
PMID: 26386179
PUBLICATIONSDataNervous System FxPNSCNS
octubre 4, 2021
The p75 neurotrophin receptor evades the endolysosomal route, favouring multivesicular bodies specialised for exosomal release in neuronal cells.
Escudero CA, Lazo OM, Galleguillos C, Parraguez JI, Lopez-Verrilli MA, Cabeza C, Leon L, Saeed U, Retamal C, Gonzalez A, Marzolo MP, Carter BD, Court FA, Bronfman FC.
J Cell Sci. 2014 May 1;127(Pt 9):1966-79. doi: 10.1242/jcs.141754. Epub 2014 Feb 25.
PMID: 24569882
PUBLICATIONSDataPNSNeuroDegeneration
octubre 4, 2021
Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction.
Villegas R, Martinez NW, Lillo J, Pihan P, Hernandez D, Twiss JL, Court FA.
J Neurosci. 2014 May 21;34(21):7179-89. doi: 10.1523/JNEUROSCI.4784-13.2014.
PMID: 24849352
octubre 4, 2021
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1.
Valdés P, Mercado G, Vidal RL, Molina C, Parsons G, Court FA, Martinez A, Galleguillos D, Armentano D, Schneider BL, Hetz C.
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6804-9. doi: 10.1073/pnas.1321845111. Epub 2014 Apr 21.
PMID: 24753614
PUBLICATIONSDataCNSNeuroRegeneration
octubre 4, 2021
Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration.
Collyer E, Catenaccio A, Lemaitre D, Diaz P, Valenzuela V, Bronfman F, Court FA.
Exp Neurol. 2014 Nov;261:451-61. doi: 10.1016/j.expneurol.2014.07.014. Epub 2014 Jul 28.
PMID: 25079366
PUBLICATIONSDataPNSNeuroRegeneration
octubre 4, 2021
Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system.
Lopez-Verrilli MA, Picou F, Court FA.
Glia. 2013 Nov;61(11):1795-806. doi: 10.1002/glia.22558. Epub 2013 Aug 30.
PMID: 24038411
PUBLICATIONSDataPNSCNSNeuroDegeneration
octubre 4, 2021
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.
Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C.
Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
PMID: 23851366
octubre 4, 2021
A BAX/BAK and cyclophilin D-Independent intrinsic apoptosis pathway.
Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C.
PLoS One. 2012;7(6):e37782. doi: 10.1371/journal.pone.0037782. Epub 2012 Jun 12.
PMID: 22719850
octubre 4, 2021
Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density.
Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SM, Gonzalez PA, Gayol S, Naranjo D, Noches V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA.
Thyroid. 2012 Sep;22(9):951-63. doi: 10.1089/thy.2010.0400. Epub 2012 Aug 7.
PMID: 22870949
PUBLICATIONSDataPNSCNSNeuroRegeneration
octubre 4, 2021
Activation of the unfolded protein response enhances motor recovery after spinal cord injury.
Valenzuela V, Collyer E, Armentano D, Parsons GB, Court FA, Hetz C.
Cell Death Dis. 2012 Feb 16;3(2):e272. doi: 10.1038/cddis.2012.8.
PMID: 22337234
PUBLICATIONSDataCNSNeuroRegeneration
octubre 4, 2021
Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy.
Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.
Hum Mol Genet. 2012 May 15;21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14.
PMID: 22337954
PUBLICATIONSDataPNSNeuroDegeneration
octubre 4, 2021
Diapause formation and downregulation of Insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss.
Calixto A, Jara JS, Court FA.
PLoS Genet. 2012;8(12):e1003141. doi: 10.1371/journal.pgen.1003141. Epub 2012 Dec 27.
PMID: 23300463
octubre 4, 2021
Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment.
Del Rio R, Muñoz C, Arias P, Court FA, Moya EA, Iturriaga R.
Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L702-11. doi: 10.1152/ajplung.00128.2011. Epub 2011 Aug 5
PMID: 21821731