The gut-brain axis along aging
The gut microbiota plays an important role in the physiology of the central nervous system and inflammation. Brain-gut communication enables bidirectional modulatory effects between the microbiota and the central nervous system, which might be involved in physiological and pathological events. Changes in the intestinal microbiota during aging show a decrease in the Firmicutes/Bacteroidetes ratio, presenting a higher proportion of Bacteroides, Clostridium, and Proteobacteria, and a decrease in Actinobacteria compared to young adults.
We are cultivating and analyzing thousands of bacterias from the Chilean population, in order to find new strains with positive effect over inflammation and aging.
Restoring the gut microbiome for healthy aging
Our research focuses on the search for bacterial consortia with effect over the aging process. Our aim is to restore the intestinal microbiota during aging, converting it into a healthier and more beneficial intestinal microbiota. For the generation of bacterial consortia, we have generated a bank of bacteria isolated from the intestinal microbiota of healthy Chileans with a wide diversity of bacteria strains. Hundreds of these isolated and taxonomically classified bacteria has been evaluated for their probiotic properties and we are currently generating consortia for in vitro and in vivo studies. In addition, we are studying the gut microbiota in aged people, trying to correlate changes in their composition associated to the risk to develop brain conditions.
People involved
Related Publications
PUBLICATIONSDataPNSNeuroDegeneration
octubre 5, 2021
Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.
Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM.
Neurobiol Dis. 2019 Oct;130:104496. doi: 10.1016/j.nbd.2019.104496. Epub 2019 Jun 6.
PMID: 31176719
PUBLICATIONSDataPNSCNSNeuroDegeneration
octubre 5, 2021
Axonal degeneration is mediated by necroptosis activation.
Arrázola MS, Saquel C, Catalán RJ, Barrientos SA, Hernandez DE, Martínez NW, Catenaccio A, Court FA.
J Neurosci. 2019 May 15;39(20):3832-3844. doi: 10.1523/JNEUROSCI.0881-18.2019. Epub 2019 Mar 8.
PMID: 30850513
PUBLICATIONSReviewPNSCNSNeuroDegeneration
octubre 5, 2021
Compartmentalized necroptosis activation in excitotoxicityinduced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology.
Arrazola MS, Court FA.
Neural Regen Res. 2019 Aug;14(8):1385-1386. doi: 10.4103/1673-5374.253520.
PMID: 30964063
PUBLICATIONSDataPNSNeuroDegeneration
octubre 5, 2021
A dual role for Integrin α6β4 in modulating Hereditary Neuropathy with liability to Pressure Palsies.
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML.
J Neurochem. 2018 May;145(3):245-257. doi: 10.1111/jnc.14295. Epub 2018 Feb 13.
PMID: 29315582
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