The gut-brain axis along aging
The gut microbiota plays an important role in the physiology of the central nervous system and inflammation. Brain-gut communication enables bidirectional modulatory effects between the microbiota and the central nervous system, which might be involved in physiological and pathological events. Changes in the intestinal microbiota during aging show a decrease in the Firmicutes/Bacteroidetes ratio, presenting a higher proportion of Bacteroides, Clostridium, and Proteobacteria, and a decrease in Actinobacteria compared to young adults.
We are cultivating and analyzing thousands of bacterias from the Chilean population, in order to find new strains with positive effect over inflammation and aging.
Restoring the gut microbiome for healthy aging
Our research focuses on the search for bacterial consortia with effect over the aging process. Our aim is to restore the intestinal microbiota during aging, converting it into a healthier and more beneficial intestinal microbiota. For the generation of bacterial consortia, we have generated a bank of bacteria isolated from the intestinal microbiota of healthy Chileans with a wide diversity of bacteria strains. Hundreds of these isolated and taxonomically classified bacteria has been evaluated for their probiotic properties and we are currently generating consortia for in vitro and in vivo studies. In addition, we are studying the gut microbiota in aged people, trying to correlate changes in their composition associated to the risk to develop brain conditions.
People involved
Related Publications
PUBLICATIONSDataPNSNeuroRegeneration
octubre 7, 2021
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile.
Lemaitre D, Hurtado ML, De Gregorio C, Oñate M, Martínez G, Catenaccio A, Wishart TM, Court FA.
Mol Neurobiol. 2020 Oct;57(10):4232-4249. doi: 10.1007/s12035-020-01986-3. Epub 2020 Jul 21.
PMID: 32696431
PUBLICATIONSDataPNSNeuroDegeneration
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Metformin protects from oxaliplatin induced peripheral neuropathy in rats.
Martinez NW, Sánchez A, Diaz P, Broekhuizen R, Godoy J, Mondaca S, Catenaccio A, Macanas P, Nervi B, Calvo M, Court FA.
Neurobiol Pain. 2020 May 22;8:100048. doi: 10.1016/j.ynpai.2020.100048. eCollection 2020 Aug-Dec.
PMID: 32490289
PUBLICATIONSDataNervous System FxPNSNeuroRegeneration
octubre 7, 2021
Schwann Cell Reprogramming Into Repair Cells Increases Exosome-Loaded miRNA-21 Promoting Axonal Growth.
López-Leal R, Díaz-Viraqué F, Catalán RJ, Saquel C, Enright A, Iraola G, Court FA.
J Cell Sci. 2020 Jun 15;133(12):jcs239004. doi: 10.1242/jcs.239004.
PMID: 32409566
PUBLICATIONSReviewNeuroDegenerationAGING
octubre 7, 2021
The Necroptosis Pathway and Its Role in Age-Related Neurodegenerative Diseases: Will It Open Up New Therapeutic Avenues in the Next Decade?
Salvadores N, Court FA.
Expert Opin Ther Targets. 2020 Jul;24(7):679-693. doi: 10.1080/14728222.2020.1758668. Epub 2020 May 4
PMID: 32310729
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